![]() ![]() However, multimorbidity (i.e., the presence of two or more chronic diseases) is the norm rather than the exception in chronic patients, especially in the elderly 9. To date, most studies on comorbidity and COVID-19 severity have analyzed the impact of some diseases individually. Cardiovascular and metabolic diseases such as obesity, heart failure, chronic renal failure, and diabetes mellitus 1, 7 have been consistently associated with a higher risk of severity, while the role of other conditions such as asthma remains unclear 8. The presence of certain chronic diseases at the time of infection seems to be another determining factor of COVID-19 severity. Nevertheless, we now know that male sex is a risk factor for poor prognosis 2, 3, 4 and that older patients, especially those over the age of 80, are more likely to develop more severe outcomes 5, 6. Severe outcomes and complications can occur at any age, even in previously healthy individuals 1. More than a year and a half later, and even though several factors related to poor prognosis have already been identified, the ongoing COVID-19 pandemic still represents a challenge for clinicians, healthcare systems and society. ![]() Immediately after the coronavirus disease (COVID-19) outbreak in December 2019, the clinical and research communities worldwide set their focus on identifying aspects that influence the disparity of symptoms and outcomes in infected individuals. These results have relevant implications for organizational, preventive, and clinical actions to help meet the needs of COVID-19 patients. In younger adults, anxiety was another disease that increased the risk of severity, most notably when combined with menstrual disorders in women or atopic dermatitis in men. We evidenced that negative outcomes were strongly related to patterns in which diabetes and obesity stood out in older women and men, respectively. Network analysis in our population revealed that not all cardiovascular patterns have the same risk of COVID-19 hospitalization or mortality and that this risk depends on the pattern of multimorbidity, besides age and sex. However, chronic diseases tend to cluster into patterns, each with its particular repercussions on the clinical outcome of infected patients. Numerous studies focused on specific chronic diseases and identified conditions, mainly cardiovascular ones, associated with poor prognosis. A major risk factor of COVID-19 severity is the patient's health status at the time of the infection. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
December 2022
Categories |